Hollywood's most eligible bachelor may be about to be taken off the market - by a member of Pakistan's greatest political dynasty.
But an American report that, despite the odds, the pair are embroiled in a secret affair, has thrown all of Pakistan into a frenzy.
The National Enquirer claimed Clooney is smitten by the 26-year-old Bhutto, an outspoken poet and journalist who lives with her brother and step-mother in a Karachi suburb. ' a frustrated commentator wrote in a Philadelphia's Metro.'George has courted her by phone and email, and arranged to meet her abroad when their schedules allowed,' a friend of the actor's told the Enquirer.
'Now he wants her to spend time with him in Hollywood.'He's still out there with his usual assortment of eye candy hanging from his arm.
George Clooney with ex-girlfriend Sarah Larson, a former cocktail waitress, at an awards gala in New York in January, 2008. ' frustrated commentators have asked But George insists those days could be coming to an end if Fatima wants to take their relationship to the next level.'But the eye candy and the long distance may not be the biggest stumbling block that Clooney faces in his quest to get the girl.
Bhutto was also said to believe their age differences made any relationship 'impractical'.
She was educated at New York's prestigious Columbia University, and well aware of Clooney's heart throb status before they met, the newspaper reported.'But she didn't take his advances seriously because she thought their age difference would make a serious relationship impractical,' it claimed.
However Clooney's profound interest in world affairs - which has often carried him into the political realm - may provide him and Bhutto with some common ground.
Bhutto is reported to be contesting her late aunt's former seat in the Larkana constituency in the next elections.
She is also a prominent intellectual who has published a book of poetry, The Whispers of the Desert, and a memoir of the 2005 Kashmir earthquake.